Document Type

Article

Publication Date

10-22-2001

Publication Title

Bioorganic & Medicinal Chemistry Letters

Volume

11

Issue

20

Publisher Name

Elsevier

Abstract

A series of α-alkyl-α-amino-β-sulphone hydroxamates was prepared and evaluated for potency versus MMP-2 and MMP-13, and for selectivity versus MMP-1. Low nanomolar potency was obtained with selectivity versus MMP-1 ranging from >10 to >1000. Selected compounds were orally bioavailable.

Comments

Author Posting © Elsevier, 2001. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Bioorganic & Medicinal Chemistry Letters, Volume 11, Issue 20, October 22, 2001. http://dx.doi.org/10.1016/S0960-894X(01)00557-1

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

Included in

Chemistry Commons

Share

COinS