Document Type

Article

Publication Date

6-21-2004

Publication Title

Bioorganic & Medicinal Chemistry Letters

Volume

14

Issue

12

Publisher Name

Elsevier

Abstract

Pyrrolizidine benzamide (±)-2, the bridgehead-methyl analog of SC-53116, was prepared and evaluated for 5-HT4 agonism activity in the rat tunica muscularis (TMM) mucosae assay. Compound (±)-2 has an EC50 of 449 nM in the TMM assay, as compared to 23 nM for SC-53116, and 66 nM for the racemate of SC-53116.

Comments

Author Posting © Elsevier, 2004. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Bioorganic & Medicinal Chemistry Letters, Volume 14, Issue 12, June 21, 2004. http://dx.doi.org/10.1016/j.bmcl.2004.04.021

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This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

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