Document Type

Article

Publication Date

9-23-2010

Publication Title

Journal of Medicinal Chemistry

Volume

53

Issue

18

Publisher Name

American Chemical Society

Abstract

α-Sulfone-α-piperidine and α-tetrahydropyranyl hydroxamates were explored that are potent inhibitors of MMP’s-2, -9, and -13 that spare MMP-1, with oral efficacy in inhibiting tumor growth in mice and left-ventricular hypertrophy in rats and in the bovine cartilage degradation ex vivo explant system. α-Piperidine 19v (SC-78080/SD-2590) was selected for development toward the initial indication of cancer, while α-piperidine and α-tetrahydropyranyl hydroxamates 19w (SC-77964) and 9i (SC-77774), respectively, were identified as backup compounds.

Comments

Author Posting © American Chemical Society, 2010. This is the author's version of the work. It is posted here by permission of American Chemical Society for personal use, not for redistribution. The definitive version was published in Journal of Medicinal Chemistry, Volume 53, Issue 18, September 23, 2010. http://dx.doi.org/10.1021/jm100669j

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Creative Commons License
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