Document Type

Article

Publication Date

2010

Publication Title

Journal of Virology

Volume

84

Issue

9

Pages

4860–4863

Publisher Name

American Society for Microbiology

Abstract

The ability for a virus to expand its host range is dependent upon a successful mode of viral entry. As such, the host range of the well-studied ΦX174 bacteriophage is dictated by the presence of a particular lipopolysaccharide (LPS) on the bacterial surface. The mutant ΦX174 strain JACS-K, unlike its ancestor, is capable of infecting both its native host Escherichia coli C and E. coli K-12, which does not have the necessary LPS. The conversion of an alanine to a very reactive threonine on its virion surface was found to be responsible for the strain's expanded host range.

Comments

Author Posting. © American Society for Microbiology, 2010. This article is posted here by permission of the American Society for Microbiology for personal use, not for redistribution. The article was published in Journal of Virology, Volume 84, Issue 9, 2010, http://dx.doi.org/10.1128/JVI.00047-10

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

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