Cross-Study Evaluation of the Relationship between the Human Gut Microbiome and Heart Disease

Heart disease is the number one cause of death globally, characterized by disorders of the arteries and blood flow. The human microbiome is a community of microorganisms that operate as a “hidden organ” to regulate healthy immune function and other beneficial effects. Recent studies have assessed the relationship between the gut microbiome and heart disease. Our work is a critical evaluation of these findings. The field of microbiome research is rapidly evolving and known biases exist. Reassessment using modern best practices and available databases can clarify the relationship between heart disease and the gut microbiome. This work may aid future translational work on the topic.