Major
Bioinformatics
Anticipated Graduation Year
2024
Access Type
Restricted Access
Abstract
Since the inception of Genome Wide Association Studies (GWAS), African populations have been sorely underrepresented in genomic sequencing in lieu of European populations, which historically have had greater access to DNA sequencing. Recent studies have shown that the composition of the gut microbiota is closely linked with coronary heart disease (CHD) risk, and our current point of interest in analyzing these studies is using Mendelian randomization to test for causality between each study, specifically in African populations.
Faculty Mentors & Instructors
Dr. Heather Wheeler, Associate Professor, Department of Biology; Camilla Czapla, Research Assistant, Department of Biology
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Modeling Causality Between Coronary Heart Disease and Newly-Classified Gut Microbiome Traits in African Ancestry Populations
Since the inception of Genome Wide Association Studies (GWAS), African populations have been sorely underrepresented in genomic sequencing in lieu of European populations, which historically have had greater access to DNA sequencing. Recent studies have shown that the composition of the gut microbiota is closely linked with coronary heart disease (CHD) risk, and our current point of interest in analyzing these studies is using Mendelian randomization to test for causality between each study, specifically in African populations.