Mapping Short Sequencing Reads to Distant Relatives

Document Type

Conference Proceeding

Publication Date

2011

Publication Title

2nd ACM Conference on Bioinformatics, Computational Biology and Biomedicine

Pages

420–424

Abstract

Numerous different algorithmic approaches have been developed to map the short-reads produced by next-generation sequencing technologies onto reference genome sequences. When sufficiently close reference genomes do not exist, less rigorous approaches must be taken, as is the case for analysis of diverse environmental samples. We have developed a new suite of data structures and algorithms specifically for the mapping of reads from environmental sequencing projects. A pipeline was developed which can rigorously map reads to genomes with many mismatches between the two. Using 50+ million reads generated from soil samples, we present the results of our performance analysis of our approach.

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Mapping short sequencing reads to distant relatives Vinicio Reynoso, Catherine Putonti
BCB '11 Proceedings of the 2nd ACM Conference on Bioinformatics, Computational Biology and Biomedicine, 2011 frames are not supported

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Author Posting. © ACM, 2011. This conference proceeding is posted here by permission of the ACM for personal use, not for redistribution. The proceeding was presented at the 2nd ACM Conference on Bioinformatics, Computational Biology and Biomedicine, 2011. https://doi.org/10.1145/2147805.2147862

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

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