Mapping Short Sequencing Reads to Distant Relatives
2nd ACM Conference on Bioinformatics, Computational Biology and Biomedicine
Numerous different algorithmic approaches have been developed to map the short-reads produced by next-generation sequencing technologies onto reference genome sequences. When sufficiently close reference genomes do not exist, less rigorous approaches must be taken, as is the case for analysis of diverse environmental samples. We have developed a new suite of data structures and algorithms specifically for the mapping of reads from environmental sequencing projects. A pipeline was developed which can rigorously map reads to genomes with many mismatches between the two. Using 50+ million reads generated from soil samples, we present the results of our performance analysis of our approach.
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Mapping short sequencing reads to distant relatives Vinicio Reynoso, Catherine Putonti
BCB '11 Proceedings of the 2nd ACM Conference on Bioinformatics, Computational Biology and Biomedicine, 2011 frames are not supported
Reynoso, V and C Putonti. " Mapping short sequencing reads to distant relatives." 2nd ACM Conference on Bioinformatics, Computational Biology and Biomedicine, 2011.
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