Selective, Orally Active MMP Inhibitors with an Aryl Backbone

Authors

Thomas Barta
Daniel P. Becker, Loyola University ChicagoFollow
Louis J. Bedell
Gary A. De Crescenzo

Document Type

Article

Publication Date

9-17-2001

Publication Title

Bioorganic & Medicinal Chemistry Letters

Volume

11

Issue

18

Pages

2481-2483

Publisher Name

Elsevier

Abstract

This letter describes SAR exploration and rat PK optimization of a series of novel, MMP-1 sparing aryl hydroxamate sulfonamides with activity against MMP-2 and MMP-13.

Comments

Author Posting © Elsevier, 2001. The definitive version was published in Bioorganic & Medicinal Chemistry Letters, Volume 11, Issue 18, September 17, http://dx.doi.org/10.1016/S0960-894X(01)00487-5

Recommended Citation

Barta, Thomas; Becker, Daniel P.; Bedell, Louis J.; and De Crescenzo, Gary A.. Selective, Orally Active MMP Inhibitors with an Aryl Backbone. Bioorganic & Medicinal Chemistry Letters, 11, 18: 2481-2483, 2001. Retrieved from Loyola eCommons, Chemistry: Faculty Publications and Other Works, http://dx.doi.org/10.1016/S0960-894X(01)00487-5

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

Copyright Statement

© 2001 Elsevier