Document Type

Article

Publication Date

6-15-2010

Publication Title

Bioorganic & Medicinal Chemistry Letters

Volume

20

Issue

12

Pages

3557-3560

Publisher Name

Elsevier

Abstract

A series of phenyl piperidine α-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13, are dual-sparing of MMP-1 and MMP-14 (MT1-MMP) and exhibit oral bioavailability in rats.

Comments

Author Posting © Elsevier, 2010. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Bioorganic & Medicinal Chemistry Letters , Volume 20, Issue 12, June 15, 2010. http://dx.doi.org/10.1016/j.bmcl.2010.04.130

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

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