Document Type

Article

Publication Date

5-15-2011

Publication Title

Bioorganic & Medicinal Chemistry Letters

Volume

21

Issue

10

Publisher Name

Elsevier

Abstract

Continuing our interest in designing compounds preferentially potent and selective for MMP-13, we report on a series of hydroxamic acids with a flexible amide P1' substituents. We identify an amide which spares both MMP-1 and -14, and shows >500 fold selectivity for MMP-13 versus MMP-2 and -8.

Comments

Author Posting © Elsevier, 2011. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Bioorganic & Medicinal Chemistry Letters, Volume 21, Issue 10, May 15, 2011. http://dx.doi.org/10.1016/j.bmcl.2011.03.095

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Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

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