Title

Characterization and Spontaneous Induction of Urinary Tract Streptococcus Anginosus Prophages

Document Type

Article

Publication Date

4-2020

Publication Title

Journal of General Virology

Volume

101

Issue

6

Pages

685-691

Publisher Name

Microbiology Society

Abstract

Streptococcus anginosus is an often overlooked and understudied emerging pathogen inhabiting many areas of the human body. Through our sequencing of S. anginosus strains isolated from the female bladder microbiota, we detected numerous prophage sequences. Bioinformatic analysis of these sequences identified 17 distinct groups of S. anginosus prophages. The majority of these phages exhibit no sequence homology to previously characterized temperate or virulent phage sequences, indicating an unexplored diversity of Streptococcus phages. By culturing these bacterial isolates, we confirmed that the prophages of five of these groups are capable of induction. One of these putative phages was imaged, the first such evidence of an S . anginosus virus-like particle; it exhibits morphological characteristics of siphoviruses.

Comments

Author Posting © The Authors, 2020. This article is posted here by permission of The Authors for personal use, not for redistribution. The article was published in Journal of General Virology, Volume 101, Issue 6, April 2020, https://doi.org/10.1099/jgv.0.001407

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