Document Type
Article
Publication Date
5-15-2011
Publication Title
Bioorganic & Medicinal Chemistry Letters
Volume
21
Issue
10
Pages
2823-2825
Publisher Name
Elsevier
Abstract
Continuing our interest in designing compounds preferentially potent and selective for MMP-13, we report on a series of hydroxamic acids with a flexible amide P1' substituents. We identify an amide which spares both MMP-1 and -14, and shows >500 fold selectivity for MMP-13 versus MMP-2 and -8.
Recommended Citation
Fobian, Yvette M.; Freskos, John N.; Barta, Thomas E.; Bedell, Louis J.; and Becker, Daniel. MMP-13 Selective Alpha-sulfone Hydroxamates: Identification of Selective P1' Amides. Bioorganic & Medicinal Chemistry Letters, 21, 10: 2823-2825, 2011. Retrieved from Loyola eCommons, Chemistry: Faculty Publications and Other Works, http://dx.doi.org/10.1016/j.bmcl.2011.03.095
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Copyright Statement
© 2011 Elsevier
Comments
Author Posting © Elsevier, 2011. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Bioorganic & Medicinal Chemistry Letters, Volume 21, Issue 10, May 15, 2011. http://dx.doi.org/10.1016/j.bmcl.2011.03.095