Date of Award


Degree Type


Degree Name

Master of Science (MS)


Microbiology and Immunology


Urinary Tract Infection (UTI) is one of the most common bacterial infections in adult women. Treatment is one of the most common reasons for antibiotic prescription. the rise of antibiotic-resistant infections coupled with the shortage of new antibiotics creates an urgent need for alternative non-antibiotic treatments. One alternative is methenamine hippurate (MH), which is a non-antibiotic prophylaxis. It is reported to be active against some common uropathogens including Escherichia coli and Enterococcus species, but its effects on the newly discovered bladder microbiota (urobiome) are undocumented. Given this knowledge gap, this study aimed to evaluate the drug's spectrum of susceptibility on UTI-relevant bacteria. Thus, I have characterized the effects of MH and its metabolites on common uropathogens and putative commensal species. We hypothesized that because of MH's unique mechanism of action, some bacteria are more strongly affected than others and, in most cases, these sensitivities cannot be predicted a priori.

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Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

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