Date of Award
Master of Science (MS)
Microbiology and Immunology
Urinary Tract Infection (UTI) is one of the most common bacterial infections in adult women. Treatment is one of the most common reasons for antibiotic prescription. the rise of antibiotic-resistant infections coupled with the shortage of new antibiotics creates an urgent need for alternative non-antibiotic treatments. One alternative is methenamine hippurate (MH), which is a non-antibiotic prophylaxis. It is reported to be active against some common uropathogens including Escherichia coli and Enterococcus species, but its effects on the newly discovered bladder microbiota (urobiome) are undocumented. Given this knowledge gap, this study aimed to evaluate the drug's spectrum of susceptibility on UTI-relevant bacteria. Thus, I have characterized the effects of MH and its metabolites on common uropathogens and putative commensal species. We hypothesized that because of MH's unique mechanism of action, some bacteria are more strongly affected than others and, in most cases, these sensitivities cannot be predicted a priori.
Sloan, Nancy, "A Susceptibility Study of Urinary Isolates to Methenamine Hippurate and its Metabolites" (2020). Master's Theses. 4350.
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Copyright © 2020 Nancy Sloan
Available for download on Wednesday, April 27, 2022