Date of Award

2021

Degree Type

Thesis

Degree Name

Master of Science (MS)

Department

Cell Biology, Neurobiology and Anatomy

Abstract

Peripheral Neuropathy is characterized as injury to the peripheral nervous system. In terms of sensory neuropathy, metabolic syndrome is involved in chronic inflammation and ER stress pathways induced by lipid overload, leading to the structural and physiological damage of afferent sensory nerves. To protect the cell from lipid-induced ER stress, Liver X Receptors (LXRs) are sterol-activated nuclear transcription factors that are of particular interest due to its role in the regulation of lipid homeostasis, membrane phospholipids, and inflammation in metabolic tissues. Their role in the peripheral nervous system remains to be elucidated. LPCAT3, regulated by LXRs, has been shown to modulate arachidonic acid's insertion into the cell membrane, a derivative of membrane phospholipids. Using transgenic mouse models, we performed ex vivo studies to determine the role of LXR in the regulation of LPCAT3 in the DRG as a potential mechanism for modulating prostaglandin synthesis to attenuate obesity-induced neuropathic pain.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

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