Document Type

Article

Publication Date

11-15-2004

Publication Title

Bioorganic & Medicinal Chemistry Letters

Volume

14

Issue

22

Pages

5509-5512

Publisher Name

Elsevier

Abstract

Azaadamantanone 1 was converted to a series of aminoazaadamantane benzamides 9a–d, which were profiled for serotonin receptor activity. Aminomethylazaadamantane SC-54750 is a potent 5-HT4 agonist and 5-HT3 antagonist with in vivo efficacy in gastroparesis models and also inhibits cisplatin-induced emesis.

Comments

Author Posting © Elsevier, 2004. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Bioorganic & Medicinal Chemistry Letters, Volume 14, Issue 22, November 15, 2004. http://dx.doi.org/10.1016/j.bmcl.2004.09.005

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

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