Document Type
Article
Publication Date
11-15-2004
Publication Title
Bioorganic & Medicinal Chemistry Letters
Volume
14
Issue
22
Pages
5509-5512
Publisher Name
Elsevier
Abstract
Azaadamantanone 1 was converted to a series of aminoazaadamantane benzamides 9a–d, which were profiled for serotonin receptor activity. Aminomethylazaadamantane SC-54750 is a potent 5-HT4 agonist and 5-HT3 antagonist with in vivo efficacy in gastroparesis models and also inhibits cisplatin-induced emesis.
Recommended Citation
Becker, Daniel; Flynn, Daniel L.; Shone, Robert L.; and Gullikson, Gary. Azaadamantane Benzamide 5-HT4 Agonists: Gastrointestinal Prokinetic SC-54750. Bioorganic & Medicinal Chemistry Letters, 14, 22: 5509-5512, 2004. Retrieved from Loyola eCommons, Chemistry: Faculty Publications and Other Works, http://dx.doi.org/10.1016/j.bmcl.2004.09.005
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Copyright Statement
© 2004 Elsevier
Comments
Author Posting © Elsevier, 2004. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Bioorganic & Medicinal Chemistry Letters, Volume 14, Issue 22, November 15, 2004. http://dx.doi.org/10.1016/j.bmcl.2004.09.005