Document Type
Article
Publication Date
6-21-2004
Publication Title
Bioorganic & Medicinal Chemistry Letters
Volume
14
Issue
12
Pages
3073-3075
Publisher Name
Elsevier
Abstract
Pyrrolizidine benzamide (±)-2, the bridgehead-methyl analog of SC-53116, was prepared and evaluated for 5-HT4 agonism activity in the rat tunica muscularis (TMM) mucosae assay. Compound (±)-2 has an EC50 of 449 nM in the TMM assay, as compared to 23 nM for SC-53116, and 66 nM for the racemate of SC-53116.
Recommended Citation
Becker, Daniel; Flynn, Daniel L.; and Villamil, Clara I.. Bridgehead-methyl Analog of SC-53116 as a 5-HT4 Agonist. Bioorganic & Medicinal Chemistry Letters, 14, 12: 3073-3075, 2004. Retrieved from Loyola eCommons, Chemistry: Faculty Publications and Other Works, http://dx.doi.org/10.1016/j.bmcl.2004.04.021
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Copyright Statement
© 2004 Elsevier
Comments
Author Posting © Elsevier, 2004. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Bioorganic & Medicinal Chemistry Letters, Volume 14, Issue 12, June 21, 2004. http://dx.doi.org/10.1016/j.bmcl.2004.04.021