New (Nor)Aza-Adamantanes Are Agonists at the Newly Identified Serotonin 5HT4 Receptor and Antagonists at the 5HT3 Receptor
Document Type
Article
Publication Date
12-1-1992
Publication Title
Bioorganic & Medicinal Chemistry Letters
Volume
2
Issue
12
Pages
1613-1618
Publisher Name
Elsevier
Abstract
New aza(nor)adamantanes 1A, 1B, and 1C are described which exhibit properties of both 5-HT4 agonism and 5-HT3 antagonism. In particular, compound 1C [SC-52491], an azanoradamantane, exhibits an EC50 of 51 nM in a functional model of 5-HT4 agonism and potent antagonism, Ki = 1.2 nM, at the 5-HT3receptor.
Recommended Citation
Flynn, Daniel L.; Becker, Daniel; Spangler, Dale P.; and Nosal, Roger. New (Nor)Aza-Adamantanes Are Agonists at the Newly Identified Serotonin 5HT4 Receptor and Antagonists at the 5HT3 Receptor. Bioorganic & Medicinal Chemistry Letters, 2, 12: 1613-1618, 1992. Retrieved from Loyola eCommons, Chemistry: Faculty Publications and Other Works, http://dx.doi.org/10.1016/S0960-894X(00)80441-2
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Copyright Statement
© 1992 Elsevier
Comments
Author Posting © Elsevier, 1992. The definitive version was published in Bioorganic & Medicinal Chemistry Letters, Volume 2, Issue 12, December 1992. http://dx.doi.org/10.1016/S0960-894X(00)80441-2