1,3,4-Trisubstituted Pyrrolidinones as Scaffolds for Construction of Peptidomimetic Cholecystokinin Antagonists
Document Type
Article
Publication Date
10-1-1992
Publication Title
Bioorganic & Medicinal Chemistry Letters
Volume
2
Issue
10
Pages
1251-1256
Publisher Name
Elsevier
Abstract
A new series of cholecystokinin (CCK) antagonists are described which utilizes a new 1,3,4-trisubstituted pyrrolidinone as a scaffold for appending specific amino acid R group mimics (Figure 1). Compound 1A and 1E (SC-50998) exhibit potent nanomolar IC50 values in a CCK-A receptor binding assay. Compound 1E behaves as a competitive antagonist in vitro and is orally active.
Recommended Citation
Flynn, Daniel L.; Villamil, Clara I.; Becker, Daniel; and Gullikson, Gary W.. 1,3,4-Trisubstituted Pyrrolidinones as Scaffolds for Construction of Peptidomimetic Cholecystokinin Antagonists . Bioorganic & Medicinal Chemistry Letters, 2, 10: 1251-1256, 1992. Retrieved from Loyola eCommons, Chemistry: Faculty Publications and Other Works, http://dx.doi.org/10.1016/S0960-894X(00)80224-3
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Copyright Statement
© 1992 Elsevier
Comments
Author Posting © Elsevier, 1992. The definitive version was published in Bioorganic & Medicinal Chemistry Letters, Volume 2, Issue 10, October 1992. http://dx.doi.org/10.1016/S0960-894X(00)80224-3