SC-53116: The First Selective Agonist at the Newly Identified Serotonin 5-HT4 Receptor Subtype
Document Type
Article
Publication Date
3-1-1992
Publication Title
Journal of Medicinal Chemistry
Volume
35
Issue
8
Pages
1486–1489
Publisher Name
American Chemical Society
Abstract
Serotonin acts as a neurotransmitter, neuromodulator, and hormone in mammals, and it is known to exhibit profound pharmacological activities in the central nervous system, autonomic nervous system, enteric nervous system, and cardiovascular system. Among monoamine neuro-transmitters, serotonin is unsurpassed in the number of receptor subtypes identified. Until recently, serotonin was thought to act through receptors subtyped as 5-HT1, 5-HT2, and 5-HT3. Furthermore, even these subtypes have been subclassed to now include 5-HT1A, 5-HT1B, 5-HTlc, 5-HT1D, 5-HT2A, 5-HT2B, and 5-HT3A ,5-HT3B ,and 5-HT33C.2
Recommended Citation
Flynn, Daniel L.; Zabrowski, Daniel; Becker, Daniel; and Nosal, Roger. SC-53116: The First Selective Agonist at the Newly Identified Serotonin 5-HT4 Receptor Subtype. Journal of Medicinal Chemistry, 35, 8: 1486–1489, 1992. Retrieved from Loyola eCommons, Chemistry: Faculty Publications and Other Works, http://dx.doi.org/10.1021/jm00086a019
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Copyright Statement
© 1992 American Chemical Society
Comments
Author Posting © American Chemical Society, 1992. The definitive version was published in Journal of Medicinal Chemistry, Volume 35, Number 8, April 1992. http://dx.doi.org/10.1021/jm00086a019