Document Type
Article
Publication Date
10-22-2020
Publication Title
Scientific Reports
Volume
10
Publisher Name
Springer Nature
Abstract
Numerous neurological dysfunctions are characterized by undesirable nerve activity. By providing reversible nerve blockage, electric stimulation with an implanted electrode holds promise in the treatment of these conditions. However, there are several limitations to its application, including poor bio-compatibility and decreased efficacy during chronic implantation. A magnetic coil of miniature size can mitigate some of these problems, by coating it with biocompatible material for chronic implantation. However, it is unknown if miniature coils could be effective in axonal blockage and, if so, what the underlying mechanisms are. Here we demonstrate that a submillimeter magnetic coil can reversibly block action potentials in the unmyelinated axons from the marine mollusk Aplysia californica. Using a multi-compartment model of the Aplysia axon, we demonstrate that the miniature coil causes a significant local depolarization in the axon, alters activation dynamics of the sodium channels, and prevents the traveling of the invading action potentials. With improved biocompatibility and capability of emitting high-frequency stimuli, micro coils provide an interesting alternative for electric blockage of axonal conductance in clinical settings.
Recommended Citation
Ye, Hui. Axonal Blockage with Microscopic Magnetic Stimulation. Scientific Reports, 10, : , 2020. Retrieved from Loyola eCommons, Biology: Faculty Publications and Other Works, http://dx.doi.org/10.1038/s41598-020-74891-3
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright Statement
© The Author(s), 2020
Included in
Biology Commons, Biomedical Engineering and Bioengineering Commons, Biophysics Commons, Computational Neuroscience Commons, Neurology Commons
Comments
Author Posting. © The Author(s), 2020. The definitive version was published in Scientific Reports, Volume 10, Article 18030, 22 October 2020.
https://doi.org/10.1038/s41598-020-74891-3