Document Type
Article
Publication Date
11-23-2021
Publication Title
Cell Reports
Volume
37
Issue
8
Pages
1-12
Publisher Name
Cell Press
Abstract
The gut microbiome exhibits extreme compositional variation between hominid hosts. However, it is unclear how this variation impacts host physiology across species and whether this effect can be mediated through microbial regulation of host gene expression in interacting epithelial cells. Here, we characterize the transcriptional response of human colonic epithelial cells in vitro to live microbial communities extracted from humans, chimpanzees, gorillas, and orangutans. We find that most host genes exhibit a conserved response, whereby they respond similarly to the four hominid microbiomes. However, hundreds of host genes exhibit a divergent response, whereby they respond only to microbiomes from specific host species. Such genes are associated with intestinal diseases in humans, including inflammatory bowel disease and Crohn's disease. Last, we find that inflammation-associated microbial species regulate the expression of host genes previously associated with inflammatory bowel disease, suggesting health-related consequences for species-specific host-microbiome interactions across hominids.
Identifier
85119507935 (Scopus)
Recommended Citation
Muehlbauer, Amanda L.; Richards, Allison L.; Alazizi, Adnan; Burns, Michael B.; Gomez, Andres; Clayton, Jonathan B.; Petrzelkova, Klara; Cascardo, Camilla; Resztak, Justyna; Wen, Xiaoquan; Pique-Regi, Roger; Luca, Francesca; and Blekhman, Ran. Interspecies variation in hominid gut microbiota controls host gene regulation. Cell Reports, 37, 8: 1-12, 2021. Retrieved from Loyola eCommons, Biology: Faculty Publications and Other Works, http://dx.doi.org/10.1016/j.celrep.2021.110057
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
