Document Type
Article
Publication Date
12-1-2022
Publication Title
Genome Biology
Volume
23
Issue
1
Pages
1-18
Publisher Name
BioMed Central
Abstract
Background: Polygenic risk scores (PRS) are valuable to translate the results of genome-wide association studies (GWAS) into clinical practice. To date, most GWAS have been based on individuals of European-ancestry leading to poor performance in populations of non-European ancestry. Results: We introduce the polygenic transcriptome risk score (PTRS), which is based on predicted transcript levels (rather than SNPs), and explore the portability of PTRS across populations using UK Biobank data. Conclusions: We show that PTRS has a significantly higher portability (Wilcoxon p=0.013) in the African-descent samples where the loss of performance is most acute with better performance than PRS when used in combination.
Identifier
85122953495 (Scopus)
Recommended Citation
Liang, Yanyu; Pividori, Milton; Manichaikul, Ani; Palmer, Abraham A.; Cox, Nancy J.; Wheeler, Heather E.; and Im, Hae Kyung. Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries. Genome Biology, 23, 1: 1-18, 2022. Retrieved from Loyola eCommons, Biology: Faculty Publications and Other Works, http://dx.doi.org/10.1186/s13059-021-02591-w
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
