Document Type
Article
Publication Date
9-22-2023
Publication Title
International Journal of Heart Failure
Volume
6
Issue
1
Pages
1-8
Publisher Name
Korean Society of Heart Failure
Abstract
Background and Objectives: Atrial fibrillation is common in patients with cardiac amyloidosis. However, the optimal anticoagulation strategy to prevent thromboembolic events in patients with cardiac amyloidosis and atrial fibrillation is unknown. This systematic review and meta-analysis compares direct oral anticoagulants (DOACs) vs. vitamin K antagonists (VKAs) in patients with cardiac amyloidosis and atrial fibrillation.
Methods: We performed a systematic literature review to identify clinical studies of anticoagulation therapies for patients with cardiac amyloidosis and atrial fibrillation. The primary outcomes of major bleeding and thrombotic events were reported using random effects risk ratios (RRs) with 95% confidence interval (CI).
Results: Our search yielded 97 potential studies and evaluated 14 full-text articles based on title and abstract. We excluded 10 studies that were review articles or did not compare anticoagulation. We included 4 studies reporting on 1,579 patients. The pooled estimates are likely underpowered due to small sample sizes. There was no difference in bleeding events for patients with cardiac amyloidosis and atrial fibrillation treated with DOACs compared to VKAs with a RR of 0.64 (95% CI, 0.38–1.10; p=0.10). There were decreased thrombotic events for patients with cardiac amyloidosis and atrial fibrillation treated with DOACs compared to VKAs with a RR of 0.50 (95% CI, 0.32–0.79; p=0.003).
Conclusions: This systematic review and meta-analysis suggests that DOACs are as safe and effective as VKAs in patients with cardiac amyloidosis and atrial fibrillation. However, more data are needed to investigate clinical differences in anticoagulation therapy in this patient population.
Recommended Citation
Lacy, Spencer C.; Kinno, Menhel; Joyce, Cara; and Yu, Mingxi D., "Direct Oral Anticoagulants in Patients With Cardiac Amyloidosis: A Systematic Review and Meta-Analysis" (2023). Biostatistics Collaborative Core: Faculty Publications and Other Works. 20.
https://ecommons.luc.edu/biostatistics_facpubs/20
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Copyright Statement
© Korean Society of Heart Failure, 2024.
Comments
Author Posting © Korean Society of Heart Failure, 2024. This article is posted here by permission of Korean Society of Heart Failure for personal use and noncommercial redistribution. This article was published open access in International Journal of Heart Failure, Vol. 6, Iss. 1 (January 2024), https://doi.org/10.36628/ijhf.2023.0031.