Document Type
Article
Publication Date
11-15-2023
Publication Title
Biomedicines
Volume
11
Issue
11
Pages
1-11
Publisher Name
MDPI
Publisher Location
Basel, Switzerland
Abstract
Cytomegalovirus (CMV) and BK Polyomavirus (BKPyV) are the most common opportunistic pathogens following kidney transplantation. We evaluated 102 patients with a median age of 63 at Edward Hines VA Hospital from November 2020 to December 2022. Our primary interest was the incidence of CMV and BKPyV infections, as well as CMV and BKPyV coinfection. Secondary interests included time to infection, rejection, and graft and patient survival. There were no statistically significant differences in patient age, donor age, race, transplant type, incidence of delayed graft function, or induction in both cohorts (any infection (N = 46) vs. those without (N = 56)). There was a 36% (37/102) incidence of CMV, a 17.6% (18/102) of BKPyV and an 8.8% (9/102) incidence of coinfection. There was a decreased incidence of CMV infection in Basiliximab induction versus antithymocyte globulin (21% and 43%). CMV risk status had no effect on the incidence of CMV infection following transplant. African American recipients had a lower incidence of BKPyV infection (12% vs. 39%), yet a higher incidence was observed in those with high cPRA (50% vs. 14%). Most CMV and/or BKPyV infections occurred within the first six months post-transplant (54%). Immunosuppression management of the elderly should continually be evaluated to reduce opportunistic infections post-transplant.
Recommended Citation
Thorndyke, Anne; Joyce, Cara; Samra, Manpreet; Cotiguala, Laura; Trotter, Christine; Aguirre, Oswaldo; Chon, W. James; Sodhi, Rupinder; and Lopez-Soler, Reynold I., "Risk Factors for CMV and BK Infections in an Elderly Veteran Population Following Kidney Transplantation: Implications for Immunosuppression Induction and Management" (2023). Biostatistics Collaborative Core: Faculty Publications and Other Works. 22.
https://ecommons.luc.edu/biostatistics_facpubs/22
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright Statement
© The Author(s), 2023.
Comments
Author Posting © The Author(s), 2023. This article is posted here by permission of MDPI for personal use and redistribution. This article was published open access in Biomedicines, Vol. 11, Iss. 11 (November 15, 2023), https://doi.org/10.3390/biomedicines11113060.