Document Type
Article
Publication Date
2-10-2022
Publication Title
Viruses
Volume
14
Issue
2
Pages
1-16
Publisher Name
MDPI
Publisher Location
Basel, Switzerland
Abstract
Understanding the magnitude of responses to vaccination during the ongoing SARS-CoV-2 pandemic is essential for ultimate mitigation of the disease. Here, we describe a cohort of 102 subjects (70 COVID-19-naïve, 32 COVID-19-experienced) who received two doses of one of the mRNA vaccines (BNT162b2 (Pfizer–BioNTech) and mRNA-1273 (Moderna)). We document that a single exposure to antigen via infection or vaccination induces a variable antibody response which is affected by age, gender, race, and co-morbidities. In response to a second antigen dose, both COVID-19-naïve and experienced subjects exhibited elevated levels of anti-spike and SARS-CoV-2 neutralizing activity; however, COVID-19-experienced individuals achieved higher antibody levels and neutralization activity as a group. The COVID-19-experienced subjects exhibited no significant increase in antibody or neutralization titer in response to the second vaccine dose (i.e., third antigen exposure). Finally, we found that COVID-19-naïve individuals who received the Moderna vaccine exhibited a more robust boost response to the second vaccine dose (p = 0.004) as compared to the response to Pfizer–BioNTech. Ongoing studies with this cohort will continue to contribute to our understanding of the range and durability of responses to SARS-CoV-2 mRNA vaccines.
Recommended Citation
Uprichard, Susan L.; O'Brien, Amornrat; Evdokimova, Monika; Rowe, Cynthia L.; Joyce, Cara; Hackbart, Matthew; Cruz Pulido, Yazmin Edith; Cohen, Courtney A.; Rock, Michelle L.; Dye, John M.; Kuehnert, Paul; Ricks, Keersten M.; Casper, Marybeth; Linhart, Lori; Anderson, Katrina; Kirk, Laura; Maggiore, Jack A.; Herbert, Andrew S.; Clark, Nina M.; Reid, Gail E.; and Baker, Susan C., "Antibody Response to SARS-CoV-2 Infection and Vaccination in COVID-19-naive and Experienced Individuals" (2022). Biostatistics Collaborative Core: Faculty Publications and Other Works. 28.
https://ecommons.luc.edu/biostatistics_facpubs/28
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright Statement
© The Author(s), 2022.
Comments
Author Posting © The Author(s), 2022. This article is posted here by permission of MDPI for personal use and redistribution. This article was published open access in Viruses, Vol. 14, Iss. 2 (February 10, 2022), https://doi.org/10.3390/v14020370.