Document Type
Article
Publication Date
3-1-2023
Publication Title
Bioorganic & Medicinal Chemistry Letters
Volume
83
Pages
1-77
Publisher Name
Elsevier
Abstract
Based on a hit from a high-throughput screen, a series of phenyltetrazole amides was synthesized and assayed for inhibitory potency against DapE from Haemophilus influenzae (HiDapE). The inhibitory potency was modest but confirmed, with the most potent analog containing an aminothiazole moiety displaying an IC50 = 50.2 ± 5.0 μM. Docking reveals a potential binding mode wherein the amide carbonyl bridges both zinc atoms in the active site, and the tetrazole forms key hydrogen bonds with Arg330.
Recommended Citation
DiPuma, Thomas; Thabthimthong, Teerana; Kelley, Emma H.; Konczak, Katherine; Beulke, Megan; Herbert, Claire A.; Habeeb Mohammad, Thahani Shifna; Starus, Anna; Nocek, Boguslaw P.; Olsen, Kenneth W.; Holz, Rick C. Prof.; and Becker, Daniel P. Ph.D.. Tetrazole-Based Inhibitors of the Bacterial Enzyme N-Succinyl-l,l-2,6-Diaminopimelic Acid Desuccinylase as Potential Antibiotics. Bioorganic & Medicinal Chemistry Letters, 83, : 1-77, 2023. Retrieved from Loyola eCommons, Chemistry: Faculty Publications and Other Works, http://dx.doi.org/10.1016/j.bmcl.2023.129177
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Copyright Statement
© Elsevier, 2023.
Comments
Author Posting © Elsevier, 2023. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Bioorganic & Medicinal Chemistry Letters, Volume 83, March 2023. https://doi.org/10.1016/j.bmcl.2023.129177