Bioorganic & Medicinal Chemistry Letters
Pyrrolizidine benzamide (±)-2, the bridgehead-methyl analog of SC-53116, was prepared and evaluated for 5-HT4 agonism activity in the rat tunica muscularis (TMM) mucosae assay. Compound (±)-2 has an EC50 of 449 nM in the TMM assay, as compared to 23 nM for SC-53116, and 66 nM for the racemate of SC-53116.
Becker, Daniel; Flynn, Daniel L.; and Villamil, Clara I.. Bridgehead-methyl Analog of SC-53116 as a 5-HT4 Agonist. Bioorganic & Medicinal Chemistry Letters, 14, 12: , 2004. Retrieved from Loyola eCommons, Chemistry: Faculty Publications and Other Works, http://dx.doi.org/10.1016/j.bmcl.2004.04.021
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