Bioorganic & Medicinal Chemistry Letters
Azaadamantanone 1 was converted to a series of aminoazaadamantane benzamides 9a–d, which were profiled for serotonin receptor activity. Aminomethylazaadamantane SC-54750 is a potent 5-HT4 agonist and 5-HT3 antagonist with in vivo efficacy in gastroparesis models and also inhibits cisplatin-induced emesis.
Becker, Daniel; Flynn, Daniel L.; Shone, Robert L.; and Gullikson, Gary. Azaadamantane Benzamide 5-HT4 Agonists: Gastrointestinal Prokinetic SC-54750. Bioorganic & Medicinal Chemistry Letters, 14, 22: , 2004. Retrieved from Loyola eCommons, Chemistry: Faculty Publications and Other Works, http://dx.doi.org/10.1016/j.bmcl.2004.09.005
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