Journal of Organic Chemistry
American Chemical Society
N,N',N''-Trimethyltribenzo-1,4,7-triazacyclononatriene has been synthesized via sequential palladium-catalyzed Buchwald-Hartwig N-arylation reactions affording the 9-membered triaza o-cyclophane in 35% overall yield. An X-ray crystal structure shows the new cyclophane to have a C(2)-symmetric saddle conformation, as compared to the crown conformation exhibited by the related carbocyclic cyclotriveratrylene (CTV).
Panagopoulos, Andria M.; Zeller, Matthias; and Becker, Daniel P.. Synthesis of an Ortho-Triazacyclophane: N,N',N''-Trimethyltribenzo-1,4,7-triazacyclononatriene. Journal of Organic Chemistry, 75, 22: , 2010. Retrieved from Loyola eCommons, Chemistry: Faculty Publications and Other Works, http://dx.doi.org/10.1021/jo1017074
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