Date of Award
2018
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Microbiology and Immunology
Abstract
Autophagy is a cellular process of degradation which degrades cellular materials in acidic organelles called lysosomes. Impairment of lysosomal degradation can lead to lysosomal storage disorders such as Parkinson's Disease. In Parkinson's Disease neurotoxic α-synuclein can spread from cell-to-cell via extracellular vesicles. We investigated the changes in extra vesicular glycans upon perturbation of autophagy using a class of glycan binding molecules termed lectins.
We found that upon induction of autophagy causes EV glycans to increase while others remained consistent. Additionally, we found that specific glycans are increased more than others. Conversely, when lysosomal degradation was impaired, we observed a decrease in EV glycans and that specific glycans decreased more than others.
Recommended Citation
Cook, Benjamin, "Investigating Autophagy, Extracellular Vesicles, and Glycobiology" (2018). Master's Theses. 3667.
https://ecommons.luc.edu/luc_theses/3667
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Copyright Statement
Copyright © 2018 Benjamin Cook
