Date of Award
6-13-2024
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Biological Science
First Advisor
Mashkoor Choudhry
Abstract
Traumatic Brain Injury (TBI) is a major cause of morbidity and mortality that afflicts millions of people in the United States annually. TBI mice had significantly increased expression of the pro-inflammatory cytokines and decreased expression of tight junction proteins CLDN5, CLDN12, and OCLD in brain lesion tissue. TBI mice exhibited a significant accumulation of FITC in the middle and distal part of the small intestine compared to sham mice. TBI mice exhibited an increase in pathogenic bacteria Enterobacteriaceae and a decrease in beneficial bacteria lactobacillus. TBI mice exhibited a trend toward an increase in permeability compared to no treatment. These findings suggest that suffering from TBI results in neuroinflammation. Future studies are planned to increase mouse numbers which will potentially lead to statistically significant differences in TBI compared to Sham.
Recommended Citation
Sullivan, Anne, "Neuroinflammation and Gut Barrier Function Post Traumatic Brain Injury" (2024). Master's Theses. 4522.
https://ecommons.luc.edu/luc_theses/4522
