Major
Neuroscience
Anticipated Graduation Year
2026
Access Type
Open Access
Abstract
PSD-95 is an important scaffolding protein located in the postsynaptic density that is abundant in glutamatergic synapses in the brain. It provides structural support for receptors in the postsynaptic membrane. It has been shown to be implicated in various neurological disorders such as Alzheimer's Disease and schizophrenia. It plays a crucial role in mediating NMDA receptor-dependent LTD, which is one of the primary mechanisms behind synaptic plasticity. NMDAR-LTD is dependent on multiple posttranslational modifications, one of which being phosphorylation. Our experiments investigated Pin1 mediated isomerization and phosphorylation of T19.
Faculty Mentors & Instructors
Dr. Jary Delgado, Assistant Professor, Department of Biology
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Phosphorylation and Isomerization of the Synaptic Scaffold Protein PSD-95
PSD-95 is an important scaffolding protein located in the postsynaptic density that is abundant in glutamatergic synapses in the brain. It provides structural support for receptors in the postsynaptic membrane. It has been shown to be implicated in various neurological disorders such as Alzheimer's Disease and schizophrenia. It plays a crucial role in mediating NMDA receptor-dependent LTD, which is one of the primary mechanisms behind synaptic plasticity. NMDAR-LTD is dependent on multiple posttranslational modifications, one of which being phosphorylation. Our experiments investigated Pin1 mediated isomerization and phosphorylation of T19.