Document Type
Article
Publication Date
12-2019
Publication Title
IBRO Reports
Volume
7
Pages
26-33
Publisher Name
Elsevier
Abstract
Non-invasive brain tissue stimulation with a magnetic coil provides several irreplaceable advantages over that with an implanted electrode, in altering neural activities under pathological situations. We reviewed clinical cases that utilized time-varying magnetic fields for the treatment of epilepsy, and the safety issues related to this practice. Animal models have been developed to foster understanding of the cellular/molecular mechanisms underlying magnetic control of epileptic activity. These mechanisms include (but are not limited to) (1) direct membrane polarization by the magnetic field, (2) depolarization blockade by the deactivation of ion channels, (3) alteration in synaptic transmission, and (4) interruption of ephaptic interaction and cellular synchronization. Clinical translation of this technology could be improved through the advancement of magnetic design, optimization of stimulation protocols, and evaluation of the long-term safety. Cellular and molecular studies focusing on the mechanisms of magnetic stimulation are of great value in facilitating this translation.
Recommended Citation
Ye, Hui and Kaszuba, Stephanie. Neuromodulation with Electromagnetic Stimulation for Seizure Suppression: From Electrode to Magnetic Coil. IBRO Reports, 7, : 26-33, 2019. Retrieved from Loyola eCommons, Biology: Faculty Publications and Other Works, http://dx.doi.org/10.1016/j.ibror.2019.06.001
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Copyright Statement
© Elsevier, 2019.
Comments
Author Posting © Elsevier, 2019. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in IBRO Reports, Volume 7, December, 2019. https://doi.org/10.1016/j.ibror.2019.06.001