Palladium(II)-Catalyzed Dicarboxymethylation of Chiral Allylic Alcohols: Chirality Transfer Affording Optically Active Diesters Containing Three Contiguous Chiral Centers

Authors

Othman Hamed
Patrick M. Henry
Daniel P. Becker, Loyola University ChicagoFollow

Document Type

Article

Publication Date

7-7-2010

Publication Title

Tetrahedron Letters

Volume

51

Issue

27

Pages

3514-3517

Publisher Name

Elsevier

Abstract

This manuscript describes the extension of Stille’s palladium-catalyzed olefin dicarbonylation reaction to chiral allylic alcohols with chirality transfer to afford the corresponding chiral alcohol functionalized with bis-carbomethoxy esters, containing three contiguous chiral centers, in good to excellent diastereoselectivities (78–98%).

Comments

Author Posting © Elsevier, 2010. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Tetrahedron Letters , Volume 51, Issue 27, July 7, 2010. http://dx.doi.org/10.1016/j.tetlet.2010.04.105

Recommended Citation

Hamed, Othman; Henry, Patrick M.; and Becker, Daniel P.. Palladium(II)-Catalyzed Dicarboxymethylation of Chiral Allylic Alcohols: Chirality Transfer Affording Optically Active Diesters Containing Three Contiguous Chiral Centers. Tetrahedron Letters, 51, 27: 3514-3517, 2010. Retrieved from Loyola eCommons, Chemistry: Faculty Publications and Other Works, http://dx.doi.org/10.1016/j.tetlet.2010.04.105

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