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Major
Biology
Anticipated Graduation Year
2021
Access Type
Open Access
Abstract
As part of the Genomics Education Partnership, The Pathways Project aims to annotate genes involved in the Insulin signaling pathway in all of the Drosophila species in order to better understand how well the Insulin pathway has been conserved throughout evolution. For my contribution to this project, I annotated the widerborst gene (wdb) which is part of the Insulin signaling pathway as it encodes the B’ regulatory subunit of PP2A. Gene annotation is the process of developing a gene model which details the exact positions of coding exons in a gene. Through using tools like BLAST, the UCSC Genome Browser, and Flybase, the gene annotation process is done using synteny with a well characterized species which, in this case, was D. Melanogaster. Through my work, I evaluated the degree of conservation of the wdb gene in two Drosophila species: D. Elegans and D. Virilis.
Community Partners
Genomics Education Partnership
Faculty Mentors & Instructors
Dr. Jennifer Mierisch, Assistant Professor, Department of Biology
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Gene Annotation of wdb Across Drosophila Species
As part of the Genomics Education Partnership, The Pathways Project aims to annotate genes involved in the Insulin signaling pathway in all of the Drosophila species in order to better understand how well the Insulin pathway has been conserved throughout evolution. For my contribution to this project, I annotated the widerborst gene (wdb) which is part of the Insulin signaling pathway as it encodes the B’ regulatory subunit of PP2A. Gene annotation is the process of developing a gene model which details the exact positions of coding exons in a gene. Through using tools like BLAST, the UCSC Genome Browser, and Flybase, the gene annotation process is done using synteny with a well characterized species which, in this case, was D. Melanogaster. Through my work, I evaluated the degree of conservation of the wdb gene in two Drosophila species: D. Elegans and D. Virilis.