Presentation Title

Cell Death Facilitated by Photodynamic Therapy

Major

Biology

Anticipated Graduation Year

2021

Access Type

Restricted Access

Abstract

Photodynamic therapy is a form of cancer treatment which utilizes photosensitizers in order to create reactive oxygen species and trigger cell death. Mammalian cells possess folate receptors and will thus take up a photosensitizer attached to folate. After immersing cells in a compound composed of BSA, folic acid, and the photosensitizer, we exposed them to light which activated the photosensitizer and facilitated cell death. In addition to investigating the efficacy of BSA-FA-ce6, we demonstrated the effects of concentration and time of exposure, hypothesizing that higher concentrations and longer exposure to light are most effective at producing cell death.

Faculty Mentors & Instructors

Stefan Kanzok, Associate Professor, Department of Biology

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

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Cell Death Facilitated by Photodynamic Therapy

Photodynamic therapy is a form of cancer treatment which utilizes photosensitizers in order to create reactive oxygen species and trigger cell death. Mammalian cells possess folate receptors and will thus take up a photosensitizer attached to folate. After immersing cells in a compound composed of BSA, folic acid, and the photosensitizer, we exposed them to light which activated the photosensitizer and facilitated cell death. In addition to investigating the efficacy of BSA-FA-ce6, we demonstrated the effects of concentration and time of exposure, hypothesizing that higher concentrations and longer exposure to light are most effective at producing cell death.