Major
Chemistry
Anticipated Graduation Year
2022
Access Type
Restricted Access
Abstract
Determining the three-dimensional structure of a protein is essential for identifying its function, localization, and how it interacts with other structures in the cell. Phosducin- like proteins (PhLP) are highly-conserved cytosolic proteins in eukaryotes which are hypothesized to function as co-chaperones in the folding of cytoskeletal proteins actin and tubulin. Although this family of proteins is highly-conserved among eukaryotes of ranging complexity, very few representative species have been characterized. As part of Dr. Kanzok’s team, our objective is to determine the three-dimensional structure of PhLP-3 from Plasmodium, Drosophila, and humans in order to better understand both its function and mechanism.
Faculty Mentors & Instructors
Dr. Stefan Kanzok, Biology Department
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Structure and function of phosducin-like protein 3 from three model organisms
Determining the three-dimensional structure of a protein is essential for identifying its function, localization, and how it interacts with other structures in the cell. Phosducin- like proteins (PhLP) are highly-conserved cytosolic proteins in eukaryotes which are hypothesized to function as co-chaperones in the folding of cytoskeletal proteins actin and tubulin. Although this family of proteins is highly-conserved among eukaryotes of ranging complexity, very few representative species have been characterized. As part of Dr. Kanzok’s team, our objective is to determine the three-dimensional structure of PhLP-3 from Plasmodium, Drosophila, and humans in order to better understand both its function and mechanism.