Major
Bioinformatics & Computational Biology
Anticipated Graduation Year
2021
Access Type
Open Access
Abstract
The annotation of genes in well-characterized signaling and metabolic pathways allows for a better understanding of the relationship between a gene’s evolution and its position within a network. Drosophila has proven to be an excellent model for studying the evolution of gene expression regulatory mechanisms, as genes in this pathway are well conserved, and Drosophila species have undergone many duplications and losses over time. This project focused on the annotation of coding spans of the Target of Rapamycin gene across Drosophila species in the Insulin Signaling pathway. In this specific analysis, it is revealed that not all isoforms are conserved, and gene structure has evolved over time.
Faculty Mentors & Instructors
Dr. Jennifer Mierisch, PhD Biology
Supported By
Loyola University Chicago
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Annotation of Genes in the Insulin Signaling Pathway Across Drosophila Species
The annotation of genes in well-characterized signaling and metabolic pathways allows for a better understanding of the relationship between a gene’s evolution and its position within a network. Drosophila has proven to be an excellent model for studying the evolution of gene expression regulatory mechanisms, as genes in this pathway are well conserved, and Drosophila species have undergone many duplications and losses over time. This project focused on the annotation of coding spans of the Target of Rapamycin gene across Drosophila species in the Insulin Signaling pathway. In this specific analysis, it is revealed that not all isoforms are conserved, and gene structure has evolved over time.