Major
Neuroscience
Anticipated Graduation Year
2021
Access Type
Open Access
Abstract
Extracellular recording of nerve activities using suction electrodes is an easy yet powerful tool in characterizing neural activities in physiology and pathological conditions. However, the key factors that determine the quality of suction electrode recording has not been fully investigated. In our study, we modeled the biophysical mechanisms underlying suction technology, and found that both the suction quality and the integrity of the neural tissue impact the shape of recorded activity. Our model also suggests, quantitatively, the importance of a tight suction for high-quality recording. Using the large nerves from our model system, Aplysia californica, we tested the model predictions.
Faculty Mentors & Instructors
Hui Ye, Associate Professor, Department of Biology
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
IMPROVING EXTRACELLULAR RECORDING TECHNOLOGY WITH SUCTION ELECTRODES
Extracellular recording of nerve activities using suction electrodes is an easy yet powerful tool in characterizing neural activities in physiology and pathological conditions. However, the key factors that determine the quality of suction electrode recording has not been fully investigated. In our study, we modeled the biophysical mechanisms underlying suction technology, and found that both the suction quality and the integrity of the neural tissue impact the shape of recorded activity. Our model also suggests, quantitatively, the importance of a tight suction for high-quality recording. Using the large nerves from our model system, Aplysia californica, we tested the model predictions.