Presenter Information

Emma MajewskiFollow
Hieu NguyenFollow

Major

Molecular Biology

Anticipated Graduation Year

2021

Access Type

Open Access

Abstract

We are interested in eph receptors and ephrin ligands as they may play a role in forming the tonotopic map in the auditory system. Our research began with screening Ephrin As in the cochlear nucleus. We assayed ephrin-A3, c-fos inductions, and acoustic-startle responses. These tests tell us what role ephrin-A3 plays and whether mice can distinguish between different frequencies. We found that ephrin-A3 is expressed in a ventral to dorsal gradient. Mice lacking ephrin-A3 have broader tonotopic bands and impaired precision of tonotopic maps. They also fail to discriminate sounds with small frequency changes.

Faculty Mentors & Instructors

Dr. Wei-Ming Yu

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

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Ephrin-A3 is Required for Tonotopic Map Precision and Auditory Functions in the Mouse Auditory Brainstem

We are interested in eph receptors and ephrin ligands as they may play a role in forming the tonotopic map in the auditory system. Our research began with screening Ephrin As in the cochlear nucleus. We assayed ephrin-A3, c-fos inductions, and acoustic-startle responses. These tests tell us what role ephrin-A3 plays and whether mice can distinguish between different frequencies. We found that ephrin-A3 is expressed in a ventral to dorsal gradient. Mice lacking ephrin-A3 have broader tonotopic bands and impaired precision of tonotopic maps. They also fail to discriminate sounds with small frequency changes.