Major
Molecular Biology
Anticipated Graduation Year
2023
Access Type
Restricted Access
Abstract
The process of gonad development and gametogenesis is crucial for the propagation of our species and the conservation of biodiversity. The gene Notch plays an important role in these processes. The goal of this experiment is to determine the transcriptional targets of Notch in the testes through RNA-sequence analysis, bioinformatics, immunohistochemistry, and in situ hybridization. These target genes will help us understand the process and regulation of spermatogenesis in Drosophila and across animal phyla. It will also pave the way for future research endeavors exploring the function of identified target genes. These genes could represent therapeutic targets for infertility.
Faculty Mentors & Instructors
Jennifer Mierisch, Associate Professor, Department of Biology, Heather Wheeler, Associate Professor, Department of Biology
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Characterization of the Role of Notch in Drosophila Testes
The process of gonad development and gametogenesis is crucial for the propagation of our species and the conservation of biodiversity. The gene Notch plays an important role in these processes. The goal of this experiment is to determine the transcriptional targets of Notch in the testes through RNA-sequence analysis, bioinformatics, immunohistochemistry, and in situ hybridization. These target genes will help us understand the process and regulation of spermatogenesis in Drosophila and across animal phyla. It will also pave the way for future research endeavors exploring the function of identified target genes. These genes could represent therapeutic targets for infertility.