Major
Biology
Anticipated Graduation Year
2022
Access Type
Restricted Access
Abstract
Our laboratory is interested in elucidating the function of Type II Collagen alpha-1 (col2a1) during vertebrate development. The zebrafish orthologue of the col2a1 gene encodes an interesting von Willebrand Factor Type-C (VWF-C) domain in its second exon that may interact with members of the TGF-β family of signaling molecules. We plan to utilize CRISPR to excise exon 2 of col2a1a, consequently excising the VWF-C domain. This will allow us to tease-out the role that the VWF-C domain plays in embryogenesis.
Faculty Mentors & Instructors
Dr. Rodney M. Dale
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Elucidating the Function of an Evolutionarily Conserved Embryonic Splice Variant of Type II Collagen During Vertebrate Development
Our laboratory is interested in elucidating the function of Type II Collagen alpha-1 (col2a1) during vertebrate development. The zebrafish orthologue of the col2a1 gene encodes an interesting von Willebrand Factor Type-C (VWF-C) domain in its second exon that may interact with members of the TGF-β family of signaling molecules. We plan to utilize CRISPR to excise exon 2 of col2a1a, consequently excising the VWF-C domain. This will allow us to tease-out the role that the VWF-C domain plays in embryogenesis.