State-dependent Neural Inhibition by Extracellular Stimulation
Abstract
Utilizing the Aplysia california buccal ganglia neurons, our research built upon previous findings concerning the presence of neuronal activity states, but demonstrate that these states play a role in the cell’s responsiveness to electrical stimulation. It was demonstrated that fast-firing neurons are more resistant to inhibitory stimulation as compared to slow-firing neurons. NEURON computational modeling revealed differences in ion channel dynamics that may underlie the differences in stimulation responsiveness that are associated with neuronal states.
State-dependent Neural Inhibition by Extracellular Stimulation
Utilizing the Aplysia california buccal ganglia neurons, our research built upon previous findings concerning the presence of neuronal activity states, but demonstrate that these states play a role in the cell’s responsiveness to electrical stimulation. It was demonstrated that fast-firing neurons are more resistant to inhibitory stimulation as compared to slow-firing neurons. NEURON computational modeling revealed differences in ion channel dynamics that may underlie the differences in stimulation responsiveness that are associated with neuronal states.