Major
Bioinformatics
Anticipated Graduation Year
2022
Access Type
Restricted Access
Abstract
The central dogma of biology describes how DNA serves as the blueprint for life; genes encoded in DNA get transcribed into RNA molecules, which get translated into proteins. Gene regulation encompasses the variety of mechanisms that control the processes of transcription and translation to create differential gene expression across organisms. Many studies have performed large sequencing projects to produce datasets of individuals’ genomes, transcriptomes, and proteomes. One method for studying these omics datasets is transcriptome-wide association studies (TWAS), which draw associations between genetically regulated expression and traits. My methodology, TWAS for protein, represents a novel approach to studying gene regulation.
Faculty Mentors & Instructors
Dr. Heather Wheeler, Loyola University Chicago Department of Biology
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Determining the Genetic Component of Protein Levels with TWAS
The central dogma of biology describes how DNA serves as the blueprint for life; genes encoded in DNA get transcribed into RNA molecules, which get translated into proteins. Gene regulation encompasses the variety of mechanisms that control the processes of transcription and translation to create differential gene expression across organisms. Many studies have performed large sequencing projects to produce datasets of individuals’ genomes, transcriptomes, and proteomes. One method for studying these omics datasets is transcriptome-wide association studies (TWAS), which draw associations between genetically regulated expression and traits. My methodology, TWAS for protein, represents a novel approach to studying gene regulation.