Major
Chemistry
Anticipated Graduation Year
2022
Access Type
Open Access
Abstract
A way to combat rising antibiotic resistance is to develop novel inhibitory compounds targeting an established bacterial enzyme essential for bacterial survival. Our research is underscored by the enzyme, N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), which is found in the lysine biosynthetic pathway of most species of bacteria. DapE catalyzes a reaction that yields a precursor for bacterial cell wall synthesis. This research focuses on making three-point modifications to the functional group moieties of one of the original hit-derived leads, a tetrazole thioether, in order to synthesize a diverse library of novel analog inhibitor compounds with improved potency and efficacy against DapE.
Faculty Mentors & Instructors
Dr. Daniel Becker, Professor, Department of Chemistry & Biochemistry: TJ DiPuma, Graduate Student, Department of Chemistry and Biochemistry
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Synthesis of Tetrazole Thioether Analogs as DapE Inhibitors as Potential Novel Antibiotics
A way to combat rising antibiotic resistance is to develop novel inhibitory compounds targeting an established bacterial enzyme essential for bacterial survival. Our research is underscored by the enzyme, N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), which is found in the lysine biosynthetic pathway of most species of bacteria. DapE catalyzes a reaction that yields a precursor for bacterial cell wall synthesis. This research focuses on making three-point modifications to the functional group moieties of one of the original hit-derived leads, a tetrazole thioether, in order to synthesize a diverse library of novel analog inhibitor compounds with improved potency and efficacy against DapE.