Major
Biomedical Engineering
Anticipated Graduation Year
2022, 2024
Access Type
Open Access
Abstract
Gap detection and frequency analysis of acoustic stimuli provide the basis for sound discrimination. Patients with impaired gap detection or frequency discrimination are often associated with several hearing disorders, including tinnitus, auditory processing disorders, language impairment, and dyslexia. Mice have emerged as the most common experimental animal model for studying human hearing impairments because of the ability to manipulate their genomes. As a result, developing an experimental setup to reliably assess gap detection and frequency discrimination abilities of mice offers the opportunity to screen animal models for understanding the pathogenic mechanisms of hearing disorders and learning disabilities.
Faculty Mentors & Instructors
Dr. Wei-Ming Yu, Assistant Professor, Biology ; Dr. Vincent Chen, Assistant Professor, Engineering
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Accessing Gap Detection & Frequency Discrimination in Mice Utilizing the Acoustic Startle Reflex
Gap detection and frequency analysis of acoustic stimuli provide the basis for sound discrimination. Patients with impaired gap detection or frequency discrimination are often associated with several hearing disorders, including tinnitus, auditory processing disorders, language impairment, and dyslexia. Mice have emerged as the most common experimental animal model for studying human hearing impairments because of the ability to manipulate their genomes. As a result, developing an experimental setup to reliably assess gap detection and frequency discrimination abilities of mice offers the opportunity to screen animal models for understanding the pathogenic mechanisms of hearing disorders and learning disabilities.