Major
Neuroscience
Anticipated Graduation Year
2023
Access Type
Open Access
Abstract
Tonotopy is when neurons at various levels of the auditory pathway are topographically arranged by their responses to different sound frequencies. Disruption of tonotopy leads to difficulty processing sound information. Ephrins/Eph receptors are molecules that are vital to axon guidance and topographic mapping during neural development. To investigate a role of ephrin-B2 in auditory circuit formation, I am assessing the ability of ephrin-B2 mutants to discriminate between frequencies. These assays will allow me to evaluate whether ephrin-B2 mutant mice have any deficits in discriminating between sound frequencies and whether ephrin-B2 plays an essential role in frequency map formation.
Faculty Mentors & Instructors
Wei-Ming, Yu, Faculty, Department of Biology
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Assessing Frequency Discrimination Ability in Ephrin-B2 Mutant Mice
Tonotopy is when neurons at various levels of the auditory pathway are topographically arranged by their responses to different sound frequencies. Disruption of tonotopy leads to difficulty processing sound information. Ephrins/Eph receptors are molecules that are vital to axon guidance and topographic mapping during neural development. To investigate a role of ephrin-B2 in auditory circuit formation, I am assessing the ability of ephrin-B2 mutants to discriminate between frequencies. These assays will allow me to evaluate whether ephrin-B2 mutant mice have any deficits in discriminating between sound frequencies and whether ephrin-B2 plays an essential role in frequency map formation.