Major
Neuroscience
Anticipated Graduation Year
2023
Access Type
Restricted Access
Abstract
The auditory system processes sound stimuli beginning at the cochlea, with spiral ganglion neurons projecting from the cochlea to transmit auditory information to the cochlear nucleus. These spiral ganglion fibers are tonotopically organized, meaning they are spatially arranged and guided based on frequency responses. The molecular mechanism behind this tonotopic organization is unknown. We present that Ephrin-B2 signaling is involved in regulating the tonotopic organization of the auditory nerve fibers along with their responses and behavior. The absence of Ephrin-B2 signaling affects the tonotopic organization which results in auditory behavior changes.
Faculty Mentors & Instructors
Dr. Wei-Ming Yu - Department of Biology; Dr. Natalia Hoshino - Department of Biology
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
The Ephrin-B2 Signal Regulates Auditory Nerve Fiber Responses and Auditory Functions During Tonotopy Development
The auditory system processes sound stimuli beginning at the cochlea, with spiral ganglion neurons projecting from the cochlea to transmit auditory information to the cochlear nucleus. These spiral ganglion fibers are tonotopically organized, meaning they are spatially arranged and guided based on frequency responses. The molecular mechanism behind this tonotopic organization is unknown. We present that Ephrin-B2 signaling is involved in regulating the tonotopic organization of the auditory nerve fibers along with their responses and behavior. The absence of Ephrin-B2 signaling affects the tonotopic organization which results in auditory behavior changes.