Major
Biology
Anticipated Graduation Year
2025
Access Type
Open Access
Abstract
MFP is a self-sufficient anticaries agent, whereas NaF effectiveness differs based on presence of toothpaste binding agents. The bacterial strain used is S. mutans. Cells will be suspended in an artificial saliva phosphate buffer (separated into triplicate beakers: control, NaF, MFP). A 2-hour pH drop, will establish treatment inhibiting acid production more effectively in a hypothetical mouth environment.
1) Is MFP more effective at inhibiting lactic acid production?
2) What is the difference in the two mechanisms (MFP: enters cell, NaF: does not)?
3) What are the levels of cellular penetration of active agents in bacterial cell (using) F-19 NMR?
Faculty Mentors & Instructors
Dr. Conrad Naleway, Instructor, Chemistry and Biochemistry; Dr. Jeremy Ritzert, Lecturer, Biology
Supported By
Colgate Palmolive Company
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Presence of Sodium Monoflurophosphate and Fluoride in Streptococcus mutans Cells
MFP is a self-sufficient anticaries agent, whereas NaF effectiveness differs based on presence of toothpaste binding agents. The bacterial strain used is S. mutans. Cells will be suspended in an artificial saliva phosphate buffer (separated into triplicate beakers: control, NaF, MFP). A 2-hour pH drop, will establish treatment inhibiting acid production more effectively in a hypothetical mouth environment.
1) Is MFP more effective at inhibiting lactic acid production?
2) What is the difference in the two mechanisms (MFP: enters cell, NaF: does not)?
3) What are the levels of cellular penetration of active agents in bacterial cell (using) F-19 NMR?